Dr. Wenjin Wang | Targeted Cancer Therapy | Young Scientist Award
The Chinese University of Hong Kong | China
Author Profile
Dr. Wenjin Wang šš¬
Postdoctoral Researcher | Tumor Photodynamic Therapy Expert | Biomolecular Phase Separation Investigator
Research Interests
- Tumor Photodynamic Therapy (PDT) š”šÆ
- Design and synthesis of novel photosensitizers for PDT.
- Development of tumor-targeted PDT using tumor-responsive AIE (Aggregation-Induced Emission) photosensitizers.
- Regulation of Biomolecular Phase Separation š§¬āļø
- Investigation into the phase separation behaviors of biomolecules like proteins and nucleic acids.
- Modulation of these processes with chemical molecules to enhance understanding of intracellular organization and function.
Professional Experience
- Postdoctoral Researcher š¢
The Chinese University of Hong Kong, Shenzhen (07/2022āPresent)- Research on bioapplications of AIE materials under Prof. Ben Zhong Tang.
- Biochemical Engineer š§Ŗ
Shenzhen BGI Research Institute (10/2017ā09/2018)- Designed and optimized unnatural nucleotides for sequencing applications.
- Laboratory Assistant š¬
Peking University Shenzhen Graduate School (11/2016ā10/2017)- Focused on unnatural amino acids and asymmetric carbene O-H bond insertion catalysis by myoglobin proteins.
- Research Associate š
Tianjin Institute of Pharmaceutical Research (08/2014ā11/2016)- Developed new hypoglycemic drugs through innovative designs and research.
Education
- Ph.D. in Chemical Biology š§«
Sun Yat-Sen University (09/2018ā06/2022)- Thesis: Antitumor mechanisms of metal complexes and their regulation on biomolecular phase separation behavior.
- M.S. in Pharmacy š
Tianjin Medical University (09/2012ā06/2015)- Research: Development of SGLT2 inhibitors and hypoglycemic activity evaluation.
- B.S. in Pharmacy š„
Tianjin Medical University (09/2008ā06/2012)
Grants and Funding š°š
- National Natural Science Foundation of China
- Ruthenium Complexes and Lipid Phase Separation in Antitumor Research (2024ā2026, RMB 300K, Principal Investigator).
- China Postdoctoral Science Foundation
- GGT-Activated AIE Photosensitizers for Tumor Photodynamic Therapy (2022ā2025, RMB 80K, Principal Investigator).
- Shenzhen Medical Research Fund
- Manipulable Aggregation of AIE Photosensitizers for Enhanced Tumor PDT (2025ā2027, RMB 800K, Principal Investigator).
- National Natural Science Foundation of China
- Phase Separation Mechanism of Antitumor Phosphor Metal Complexes (2022ā2025, RMB 630K, Major Participant).
- Yunnan Province Science and Technology Plan
- Aggregate Induced Luminescence in Biomass Resources (2024ā2026, RMB 2000K, Major Participant).
Awards and Honors šāØ
- Excellent Postdoctoral Doctor (Shenzhen, 12/2023).
- National Scholarship for Doctoral Students (12/2021).
- “Fran” Excellent Thesis Scholarship (Second Class, Sun Yat-sen University, 11/2021).
- Excellent Wall Poster Award (32nd Academic Annual Meeting, Chinese Chemical Society, 04/2021).
Key Contributions š
Dr. Wangās groundbreaking research combines innovative photodynamic therapies and the manipulation of biomolecular phase separation, driving advancements in cancer treatment and molecular biology.
šš¬NOTABLE PUBLICATION:
- Title: Multi-Stimuli-Responsive and Cell Membrane Camouflaged Aggregation-Induced Emission Nanogels for Precise Chemo-photothermal Synergistic Therapy of Tumors
- Authors: Zhang, L.; Wang, Z.; Zhang, R.; … Zhao, Z.; Tang, B.Z.
- Journal: ACS Nano
- Year: 2023
- Title: Multi-site isomerization of synergistically regulated stimuli-responsive AIE materials toward multi-level decryption
- Authors: Zhong, W.; Zhang, J.; Lin, Y.; … Cai, X.-M.; Tang, B.Z.
- Journal: Chemical Science
- Year: 2024
- Title: Chromene-based BioAIEgens: āin-waterā synthesis, regiostructure-dependent fluorescence and ER-specific imaging
- Authors: Cai, X.-M.; Lin, Y.; Zhang, J.; … Zhao, Z.; Tang, B.Z.
- Journal: National Science Review
- Year: 2023
- Title: Natural Acceptor of Coumarin-Isomerized Red-Emissive BioAIEgen for Monitoring CuĀ²āŗ Concentration in Live Cells via FLIM
- Authors: Cai, X.-M.; Li, S.; Wang, W.-J.; … Zhao, Z.; Tang, B.Z.
- Journal: Advanced Science
- Year: 2024
- Title: Room Temperature Phosphorescent Nanofiber Membranes by Bio-Fermentation
- Authors: Nie, X.; Gong, J.; Ding, Z.; … Qiu, Z.; Tang, B.Z.
- Journal: Advanced Science
- Year: 2024