Dr. Wenjin Wang | Targeted Cancer Therapy | Young Scientist Award

The Chinese University of Hong Kong | China

Author Profile

Scopus

Dr. Wenjin Wang 🌟🔬

Postdoctoral Researcher | Tumor Photodynamic Therapy Expert | Biomolecular Phase Separation Investigator

Research Interests

Tumor Photodynamic Therapy (PDT) 💡🎯
- Design and synthesis of novel photosensitizers for PDT.
- Development of tumor-targeted PDT using tumor-responsive AIE (Aggregation-Induced Emission) photosensitizers.
Regulation of Biomolecular Phase Separation 🧬⚛️
- Investigation into the phase separation behaviors of biomolecules like proteins and nucleic acids.
- Modulation of these processes with chemical molecules to enhance understanding of intracellular organization and function.

Professional Experience

Postdoctoral Researcher 🏢
The Chinese University of Hong Kong, Shenzhen (07/2022–Present)
- Research on bioapplications of AIE materials under Prof. Ben Zhong Tang.
Biochemical Engineer 🧪
Shenzhen BGI Research Institute (10/2017–09/2018)
- Designed and optimized unnatural nucleotides for sequencing applications.
Laboratory Assistant 🔬
Peking University Shenzhen Graduate School (11/2016–10/2017)
- Focused on unnatural amino acids and asymmetric carbene O-H bond insertion catalysis by myoglobin proteins.
Research Associate 💊
Tianjin Institute of Pharmaceutical Research (08/2014–11/2016)
- Developed new hypoglycemic drugs through innovative designs and research.

Education

Ph.D. in Chemical Biology 🧫
Sun Yat-Sen University (09/2018–06/2022)
- Thesis: Antitumor mechanisms of metal complexes and their regulation on biomolecular phase separation behavior.
M.S. in Pharmacy 💊
Tianjin Medical University (09/2012–06/2015)
- Research: Development of SGLT2 inhibitors and hypoglycemic activity evaluation.
B.S. in Pharmacy 🏥
Tianjin Medical University (09/2008–06/2012)

Grants and Funding 💰📚

National Natural Science Foundation of China
- Ruthenium Complexes and Lipid Phase Separation in Antitumor Research (2024–2026, RMB 300K, Principal Investigator).
China Postdoctoral Science Foundation
- GGT-Activated AIE Photosensitizers for Tumor Photodynamic Therapy (2022–2025, RMB 80K, Principal Investigator).
Shenzhen Medical Research Fund
- Manipulable Aggregation of AIE Photosensitizers for Enhanced Tumor PDT (2025–2027, RMB 800K, Principal Investigator).
National Natural Science Foundation of China
- Phase Separation Mechanism of Antitumor Phosphor Metal Complexes (2022–2025, RMB 630K, Major Participant).
Yunnan Province Science and Technology Plan
- Aggregate Induced Luminescence in Biomass Resources (2024–2026, RMB 2000K, Major Participant).

Awards and Honors 🏆✨

Excellent Postdoctoral Doctor (Shenzhen, 12/2023).
National Scholarship for Doctoral Students (12/2021).
“Fran” Excellent Thesis Scholarship (Second Class, Sun Yat-sen University, 11/2021).
Excellent Wall Poster Award (32nd Academic Annual Meeting, Chinese Chemical Society, 04/2021).

Key Contributions 📈

Dr. Wang’s groundbreaking research combines innovative photodynamic therapies and the manipulation of biomolecular phase separation, driving advancements in cancer treatment and molecular biology.

📊🔬NOTABLE PUBLICATION:

Title: Multi-Stimuli-Responsive and Cell Membrane Camouflaged Aggregation-Induced Emission Nanogels for Precise Chemo-photothermal Synergistic Therapy of Tumors
- Authors: Zhang, L.; Wang, Z.; Zhang, R.; … Zhao, Z.; Tang, B.Z.
- Journal: ACS Nano
- Year: 2023

Title: Multi-site isomerization of synergistically regulated stimuli-responsive AIE materials toward multi-level decryption
- Authors: Zhong, W.; Zhang, J.; Lin, Y.; … Cai, X.-M.; Tang, B.Z.
- Journal: Chemical Science
- Year: 2024

Title: Chromene-based BioAIEgens: ‘in-water’ synthesis, regiostructure-dependent fluorescence and ER-specific imaging
- Authors: Cai, X.-M.; Lin, Y.; Zhang, J.; … Zhao, Z.; Tang, B.Z.
- Journal: National Science Review
- Year: 2023

Title: Natural Acceptor of Coumarin-Isomerized Red-Emissive BioAIEgen for Monitoring Cu²⁺ Concentration in Live Cells via FLIM
- Authors: Cai, X.-M.; Li, S.; Wang, W.-J.; … Zhao, Z.; Tang, B.Z.
- Journal: Advanced Science
- Year: 2024

Title: Room Temperature Phosphorescent Nanofiber Membranes by Bio-Fermentation
- Authors: Nie, X.; Gong, J.; Ding, Z.; … Qiu, Z.; Tang, B.Z.
- Journal: Advanced Science
- Year: 2024

Author Profile

EARLY ACADEMIC PURSUITS:

Linxi Zhu commenced her academic journey at Nanjing University, where she pursued a Bachelor's degree from July 2015 to June 2020. Following her undergraduate studies, she continued her academic pursuit at the same institution, earning a Master's degree from July 2020 to June 2021. Linxi Zhu then advanced further in her educational journey, undertaking a Ph.D. program at Nanjing University from July 2021 to June 2023.

PROFESSIONAL ENDEAVORS:

Since September 2023, Linxi Zhu has been serving as a Surgeon at Nanjing Drum Tower Hospital, marking a significant transition from academic pursuits to practical application in the field of surgery.

CONTRIBUTIONS AND RESEARCH FOCUS ON CANCER GENETICS :

Linxi Zhu's research has made notable contributions to the field of cancer genetics. Notably, her work titled "Loss of Claudin-1 incurred by DNMT aberration promotes pancreatic cancer progression" (published in Cancer Lett., 2024) sheds light on the molecular mechanisms underlying pancreatic cancer progression. Additionally, she has contributed to the development and validation of a nomogram for predicting post-operative abdominal infection in patients undergoing pancreaticoduodenectomy, as well as exploring the role of preoperative biliary drainage in postoperative outcomes after pancreaticoduodenectomy.

IMPACT AND INFLUENCE:

Zhu's research impact extends beyond pancreatic cancer, with contributions to the field of intrahepatic cholangiocarcinoma. Her collaborative work on high endothelial venule as a prognostic immune-related biomarker in patients with resected intrahepatic cholangiocarcinoma (published in Cell Prolif., 2023) underscores her diverse research interests.

ACADEMIC CITES:

Linxi Zhu has published in reputable journals, evident from her publications in Cancer Lett., Clin Chim Acta, Gland Surg, Cell Prolif., and Front Oncol. The citations received for her work demonstrate its scholarly significance and recognition within the academic community.

LEGACY AND FUTURE CONTRIBUTIONS:

Zhu's legacy lies in her comprehensive understanding of pancreatic cancer and related surgical interventions. Her research on individualized chemotherapy combined with sequential immunotherapy based on BRCA1 mRNA expression level in unresectable pancreatic cancer showcases innovative approaches. Looking forward, Linxi Zhu is poised to contribute further to the field, leaving a lasting impact on surgical and oncological research.