PK of Infigratinib in FGFR2-Amplified Gastric Cancer #oncology #pencis #lecture #Infigratinib #viral
Infigratinib, a potent FGFR1-3 tyrosine kinase inhibitor, has shown promise in targeting cancers with FGFR aberrations. This study evaluates the pharmacokinetics (PK) of infigratinib and its active metabolites in Chinese ...patients with advanced gastric cancer characterized by FGFR2 gene amplification. The research explores absorption, distribution, metabolism, and elimination profiles, while correlating these factors with therapeutic outcomes and tolerability.
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PK of Infigratinib in FGFR2-Amplified Gastric Cancer #oncology #pencis #lecture #Infigratinib #viral
Infigratinib, a potent FGFR1-3 tyrosine kinase inhibitor, has shown ...
Infigratinib, a potent FGFR1-3 tyrosine kinase inhibitor, has shown promise in targeting cancers with FGFR aberrations. This study evaluates the pharmacokinetics (PK) of infigratinib and its active metabolites in Chinese ...patients with advanced gastric cancer characterized by FGFR2 gene amplification. The research explores absorption, distribution, metabolism, and elimination profiles, while correlating these factors with therapeutic outcomes and tolerability.
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Photodynamic therapy (PDT) is a non-invasive therapeutic approach for ...
Photodynamic therapy (PDT) is a non-invasive therapeutic approach for treating cancers that involves light, a photosensitizer, and oxygen to generate reactive oxygen species (ROS) that kill cancer cells. Traditional photosensitizers ...often face challenges such as low photostability, insufficient ROS generation, and aggregation-induced quenching (AIQ).
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Photosensitizer for DNA Repair in Ovarian Cancer #oncology #pencis #lecture #ovariancancer #viral
This groundbreaking approach integrates molecular-targeting and ...
This groundbreaking approach integrates molecular-targeting and photo-immunotherapy to combat ovarian cancer. A novel photosensitizer is designed to target the DNA damage repair system, disrupting the cancer cells' ability to repair ...themselves. Simultaneously, it activates the cGAS-STING pathway, a critical immune response mechanism that enhances anti-tumor immunity.
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Statins & Coronary Artery Spasm: A Nationwide Study #oncology #pencis #lecture #statins #viralvideo
This study investigates the impact of statin therapy on patients ...
This study investigates the impact of statin therapy on patients diagnosed with coronary artery spasm (CAS), a condition characterized by temporary constriction of coronary arteries leading to chest pain, ischemia, ...or even myocardial infarction. Using a comprehensive, nationwide population-based dataset, researchers aimed to determine whether statins, known for their lipid-lowering and pleiotropic effects, can reduce adverse cardiovascular outcomes in CAS patients.
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MAD2L1 Fuels CRC Growth & Drug Resistance via Wnt/Ī²-Catenin #oncology #pencis #lecture #BetaCatenin
Mitotic Arrest Deficient 2 Like 1 (MAD2L1) is a critical player in ...
Mitotic Arrest Deficient 2 Like 1 (MAD2L1) is a critical player in cell cycle regulation and has been identified as a contributor to colorectal cancer (CRC) progression. This study explores ...the role of MAD2L1 in enhancing colorectal cancer cell migration, invasion, and resistance to oxaliplatin, a commonly used chemotherapeutic agent. Findings reveal that MAD2L1 activates the Wnt/Ī²-Catenin signaling pathway, promoting epithelial-mesenchymal transition (EMT) and increasing tumor aggressiveness.
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Origins & molecular effects of hypoxia in cancer #oncology #pencis #researchers #hypoxia #viralvideo
Hypoxia is a condition characterized by reduced oxygen availability in ...
Hypoxia is a condition characterized by reduced oxygen availability in tissues. It plays a crucial role in the initiation, progression, and metastasis of cancer. Tumor hypoxia primarily arises due to ...the rapid and disorganized growth of cancer cells, which outpaces the development of functional blood vessels.
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A pH-responsive microneedle patch designed for the transdermal ...
A pH-responsive microneedle patch designed for the transdermal delivery of biomineralized insulin nanoparticles represents a novel advancement in diabetes management. This innovative patch consists of microneedles that penetrate the skin's ...outer layer to deliver insulin directly into the bloodstream.
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HER2, KRAS & MET CNGs: Survival Impact in NSCLC via NGS #oncology #pencis #lecture #Oncogene #viral
The study titled "Use of Oncogene Overlap by Tissue-Based ...
The study titled "Use of Oncogene Overlap by Tissue-Based Next-Generation Sequencing to Explore the Mutational Landscape and Survival Impact of HER2, KRAS, and MET Copy-Number Gain in Non-Small Cell Lung ...Cancer" delves into the genomic alterations and their clinical implications in nonsmall cell lung cancer (NSCLC).
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Bisindole natural products are a unique class of compounds ...
Bisindole natural products are a unique class of compounds characterized by two indole units within their chemical structure. Found predominantly in marine organisms, plants, and certain microorganisms, these compounds exhibit ...a diverse range of biological activities, including exceptional anticancer properties. Their potent cytotoxicity and ability to target various cancer pathways make them promising candidates for drug discovery.
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CoQ10 in Pakistani Breast Cancer Patients #oncology #pencis #researchers #breastcancer #viralvideo
This study focuses on assessing the levels of Coenzyme Q10 (CoQ10) in ...
This study focuses on assessing the levels of Coenzyme Q10 (CoQ10) in Pakistani female patients diagnosed with breast cancer. CoQ10 is a vital antioxidant that plays a critical role in ...cellular energy production and protection against oxidative stress. Its deficiency has been associated with the development and progression of various cancers, including breast cancer.
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Cardiotoxicity in Cancer Care: The Oncology Nurse Role #oncology #pencis #lecture #cancercare #viral
Cardiotoxicity, a significant complication of many cancer treatments, ...
Cardiotoxicity, a significant complication of many cancer treatments, can manifest as heart failure, arrhythmias, or other cardiac dysfunctions. Chemotherapeutic agents like anthracyclines and targeted therapies, including HER2 inhibitors, are among ...the culprits. Oncology nurses play a critical role in managing and mitigating this risk through patient education, early detection, and supportive care.
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Metatypical basal cell carcinoma (MBCC), a rare and aggressive variant ...
Metatypical basal cell carcinoma (MBCC), a rare and aggressive variant of basal cell carcinoma, presents unique challenges in treatment due to its invasive nature and potential for recurrence. This case ...report highlights a successful approach to managing MBCC that achieved both an optimal oncologic outcome and a favorable aesthetic result.
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Upcoming Conferences
22nd Edition of Oncology Summit | 20-22 August 2024 | Berlin, Germany,
23rd Edition of Oncology Summit | 15-17 October 2024 | Paris, France (Hybrid)
24th Edition of Oncology Summit | 04-06 December 2024 | Dubai, United Arab Emirates (Hybird)
25th Edition of Oncology Summit | 18-21 February 2025 | Amsterdam, Netherlands (Hybrid)
26th Edition of Oncology Summit | 16-19 April 2025 | London, United Kingdom (Hybird)