📚 Biography: Dr. Stavros Melemenidis

🎓 Education

• DPhil in Radiation Biology – University of Oxford, Dept. Radiation Oncology, Oxford, UK (2010-2015)
  • Mentors: Prof. Nicola Sibson, Prof. Ruth Muschel
  • Thesis: Development of molecular targeted imaging methods for the detection of lung metastasis and angiogenesis
• M.Sc. in Radiation Biology – University of Oxford, Dept. Radiation Oncology, Oxford, UK (2009-2010)
• M.Sc. in Radiometrics – University of Liverpool, Dept. Physics, Liverpool, UK (2008-2009)
• B.Sc. in Physics: Medical Applications – University of Liverpool, Dept. Physics, Liverpool, UK (2005-2008)
• A.Eng. in PC Systems and Peripheral Equipment – IIEK Neapoleos, Technical College, Thessaloniki, Greece (1998-2000)
• Cert. Medical Physics – UCLA, Dept. Radiation Oncology, Los Angeles, CA, USA (2022-2023)

🏢 Current Position

• Director of Pre-clinical Radiotherapy – Dept. of Radiation Oncology, Stanford University (Jan 2023-present)
• Research Scientist – Div. of Radiation Therapy, Stanford University (Feb 2020-present)

🔬 Research Experience & Skills

• Stanford University, Dept. Radiation Oncology, Stanford, CA
  • Director of Pre-clinical Radiotherapy Core (Jun 2023-present)
    • Calibration of preclinical orthovoltage irradiators
    • Monthly and annual quality checks for dosimetric consistency
    • Innovation in animal radiation shielding via 3D design and additive manufacturing
  • Basic Life Research Scientist at Div. of Radiation Therapy (Jun 2020-present)
    • Pioneering preclinical ultra-high dose-rate (FLASH) irradiation experiments
    • Specializing in 3D-designed radiation shielding for animal safety
    • Expertise in dosimetry using radiochromic film and ion chambers
    • Development of animal models involving tumor implantation and microsurgical techniques
  • Postdoctoral Fellow (Feb 2016-Jun 2020)
    • Advisor: Edward E. Graves
    • Led development of in vivo mouse tumor models integrating imaging, radiotherapy, and immunotherapy
    • Specialized in ultrasound-guided injection techniques
    • Conducted research into immune cell migration with a focus on macrophage imaging
    • Evaluated radioprotective strategies for healthy tissue through drug development
  • Postdoctoral Fellow at University of Oxford, Dept. Radiation Oncology (Jan 2015-Sep 2015)
    • Advisor: Nicola R. Sibson
    • Designed and evaluated innovative imaging probes for metastasis detection and angiogenesis visualization
    • Developed dual MRI/PET probe for metastasis and MRI probe for angiogenesis
    • Managed international research collaboration with Duke University

📜 Selected Publications

• In vivo PET detection of lung micrometastasis by targeting endothelial VCAM-1. Int J Mol Sci, 2024.
• Multi-institutional audit of FLASH and conventional dosimetry with a 3D-printed anatomically realistic mouse phantom. Int J Radiat Oncol Biol Phys, 2023.
• Exploring deep learning for estimating the isoeffective dose of FLASH irradiation from mouse intestinal histological images. J Radiat Oncol Biol Phys, 2023.
• Human enteroids as a tool to study conventional and ultra-high dose rate radiation. Integr Biol (Camb), 2023.
• Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1. J Clin Invest, 2023.

🏆 Awards & Honors

• Recognition of Excellent Research: Aegean Conferences: 12th International Conference on Complement Therapeutics, Rhodes, Greece, 2019
• Poster Prize: Aegean Conferences: 3rd International Conference for Tumor Microenvironment and Cellular Stress, Greece, Mykonos, 2014

🗣️ Conference Presentations

• Oral Presentation: Demonstrating FLASH effectiveness against CONV dose rates, 34th ACRO Summit, Orlando, FL, March 2024
• Poster Presentation: Anatomically Realistic 3D Printed Mouse Phantom for Multi-Institutional Benchmarking of FLASH and CONV Irradiation, 65th ASTRO Annual Meeting San Diego, USA, Oct 2023

📞 References

• Prof. Billy W Loo Jr: Professor of Radiation Oncology (Radiation Therapy), Stanford University School of Medicine
• Prof. Edward E Graves: Associate Professor of Radiation Oncology and Director of Molecular Imaging Program, Stanford University School of Medicine
• Prof. Frederick M Dirbas: Associate Professor of Surgery (General Surgery), Stanford University School of Medicine

Dr. Stavros Melemenidis is a distinguished figure in radiation oncology, with a profound impact on preclinical radiotherapy and FLASH irradiation research. His contributions to innovative imaging techniques and his dedication to advancing cancer treatment methodologies are reflected in his extensive publication record and numerous accolades.

• • Endogenous Retroviral Elements Generate Pathologic Neutrophils in Pulmonary Arterial Hypertension
    • Authors: Taylor, S., Isobe, S., Cao, A., … Snyder, M.P., Rabinovitch, M.
    • Journal: American Journal of Respiratory and Critical Care Medicine
    • Year: 2022

• • Design and Validation of a Dosimetric Comparison Scheme Tailored for Ultra-High Dose-Rate Electron Beams to Support Multicenter FLASH Preclinical Studies
    • Authors: Jorge, P.G., Melemenidis, S., Grilj, V., … Loo, B.W., Bailat, C.
    • Journal: Radiotherapy and Oncology
    • Year: 2022

• • Real-Time Optical Oximetry During FLASH Radiotherapy Using a Phosphorescent Nanoprobe
    • Authors: Ha, B., Liang, K., Liu, C., … Loo, B.W., Pratx, G.
    • Journal: Radiotherapy and Oncology
    • Year: 2022

• • FLASH-RT Does Not Affect Chromosome Translocations and Junction Structures Beyond That of CONV-RT Dose-Rates
    • Authors: Barghouth, P.G., Melemenidis, S., Montay-Gruel, P., … Vozenin, M.-C., Frock, R.L.
    • Journal: Radiotherapy and Oncology
    • Year: 2023

• • Exploring Deep Learning for Estimating the Isoeffective Dose of FLASH Irradiation From Mouse Intestinal Histological Images
    • Authors: Fu, J., Yang, Z., Melemenidis, S., … Loo, B.W., Gu, X.
    • Journal: International Journal of Radiation Oncology Biology Physics
    • Year: 2024