Dr. Laila Jaragh-Alhadad research’s interest focuses on design, synthesis, characterize & biologically evaluate anticancer agents that target small molecules which have essential roles elevating in cancer cell division. First project area is targeting both HSP27 & HER2 proteins with inhibitors in several human cancer cell lines to improve the ADME profile. HSP27 and HER2 proteins are both attractive molecular targets for cancer therapy because of their cellular functions, which are proportionally up and down regulated in cancer cells. The goal is to synthesize a library of compounds targeting HSP27 and stabilize HER2 through HER2 pathway and choose the best drug candidate for further in-vivo evaluations. The development of this series of anticancer agents may overcome the chemotherapy drug resistance and improve the survival of cancer patients. Second project area is the strategies and techniques for drug delivery to accumulate a certain amount of the drug to some part of the body relative to others. The goal is to encapsulate the drug candidate into nanoparticles such as low-density lipoprotein, liposomes & cholesterol conjugates to mimic the natural lipid metabolic pathway to reach the center of cancer cells, to improve the drug efficacy, delivery and minimizing the side effects.
New fields under our focus is targeting tubulin protein that has important cellular roles in cell proliferation. Other cancer fields are Angiogenesis I, II and photoelectric Agents.
Benefit from the drugs that are already in the market and change their skeleton by applying the structure activity relationship (SAR) to change them to anticancer drugs useful for cancer patient’s treatment. Congratulation for Best Research Award by pencis
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