Prof Dr. Yinyuan Ding | Tumorigenesis | Best Researcher Award

Chongqing Medical University | China

Author Profile

Professor Yinyuan Ding

🌟 Professor of Oncology
🏥 Chongqing Medical University

🎓 Academic and Professional Background:

Professor Yinyuan Ding obtained a Ph.D. from Peking University in 2011 and pursued postdoctoral training at UT Southwestern Medical Center, where he was later promoted to Assistant Professor in 2018. In 2019, he returned to China and joined Chongqing Medical University as a professor. His research explores tumorigenesis and glucolipid metabolic disorders, focusing on the LRP1 receptor’s role in liver and vascular signaling, with implications for novel treatments for Hepatocellular Carcinoma (HCC) and Metabolic Associated Steatohepatitis-Liver Disease (MASLD).

🔬 Research and Innovations:

Principal Investigator
2023-2026: “The role of LRP1 in hepatic glucose metabolism and HCC progression” (National Natural Science Foundation of China)
2021: “The role of Asprosin in hepatocellular carcinoma” (Chongqing Municipal Human Resources Bureau)

Participant
2015-2020: “VLDL and ApoE receptors metabolism” (NIH-NHLBI)
2011-2015: “Cell signaling and cholesterol-lipoprotein receptors” (NIH)

📚 Journals Published:

Advanced Science, Elife, Science Signaling, EBioMedicine, JBC

🤝 Collaborations:

Collaborates with Joachim Herz (UT Southwestern Medical Center, USA)

👥 Professional Memberships:

Director of the China Branch, International Atherosclerosis Society

🧬 Areas of Research:

Oncology
Tumorigenesis
Hepatology
Lipoprotein & Lipid Research

📝 Contributions:

Professor Ding’s groundbreaking research on LRP1 has revealed its multifaceted roles in regulating cholesterol and glucose metabolism. His work identified a critical mechanism by which LRP1 affects hepatic insulin resistance, dyslipidemia, and HCC progression. This novel insight into LRP1’s function opens pathways for innovative therapeutic strategies for cancer and metabolic disorders.

✨Conclusion:

In summary, Professor Yinyuan Ding is a distinguished expert in oncology and hepatology, with a strong focus on the molecular mechanisms of tumorigenesis and lipid metabolism disorders. His innovative research on LRP1 has led to significant breakthroughs in understanding liver disease and cancer progression, paving the way for novel therapeutic strategies. With a wealth of experience from top institutions and numerous prestigious publications and patents, Professor Ding continues to make impactful contributions to the field of cancer research, driving advancements in both basic science and clinical applications. 🌟

📊🔬NOTABLE PUBLICATION:

1. LRP1 facilitates hepatic glycogenesis by improving the insulin signaling pathway in HFD-fed mice

Authors: Guo, X., Pu, J., Tang, Z., Liu, T., Ding, Y.
Journal: Animal Models and Experimental Medicine
Year: 2024

2. Erratum: Correction: LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis

Authors: Xian, X., Ding, Y., Dieckmann, M., Tsai, S., Herz, J.
Journal: eLife
Year: 2017 (Erratum published in 2024)

3. Loss of LRP1 Promotes Hepatocellular Carcinoma Progression via UFL1-Mediated Activation of NF-κB Signaling

Authors: Guo, X., Yang, F., Liu, T., Herz, J., Ding, Y.
Journal: Advanced Science
Year: 2024

Author Profile

👩‍🔬 Grazia Tamma

Position: Associate Professor of Physiology (BIO09)
Affiliation: Department of Bioscience, Biotechnologies and Pharmacological Science, University of Bari, Italy

🎓 Education:

Degree in Biological Sciences, University of Bari (1999)
PhD in Cellular and Molecular Technologies in Physiology (2003)

🔬 Research Interests:

Grazia Tamma’s research focuses on intracellular signal transduction, body and renal water homeostasis, and molecular alterations associated with oxidative stress in health and diseases.

📚 Publications:

She has published 86 papers in international scientific journals, 7 book chapters, and presented over 90 abstracts in international meetings.

🏆 Awards:

Recipient of the Italian Society of Physiology Award (2007)

🌍 International Collaborations:

Collaborates with institutions including FMP Berlin (Germany), University of Innsbruck (Austria), and University of Nijmegen (The Netherlands).

🎓 Teaching:

Teaches physiology at the Department of Biosciences, Biotechnologies and Pharmacological Science, University of Bari.

🔍 Research Projects:

Principal investigator and participant in various national and international research projects focusing on renal physiology and aquaporins.

📝 Grant Responsibilities:

Currently leading projects on hyponatremia, nephropathic cystinosis, and sustainable food technologies.

This bio encapsulates Grazia Tamma’s academic journey, research contributions, and professional engagements with relevant titles and emojis.

📊🔬Notable Publication:

Promising Application of Grape Pomace and Its Agri-Food Valorization: Source of Bioactive Molecules with Beneficial Effects

Authors: Caponio, G.R., Minervini, F., Tamma, G., Gambacorta, G., De Angelis, M.
Journal: Sustainability (Switzerland)
Year: 2023

circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in small cell lung cancer

Authors: Tolomeo, D., Traversa, D., Venuto, S., Vacca, A., Storlazzi, C.T.
Journal: Genes Chromosomes and Cancer
Year: 2023

AQP2 trafficking in health and diseases: an updated overview

Authors: Centrone, M., Ranieri, M., Di Mise, A., Valenti, G., Tamma, G.
Journal: International Journal of Biochemistry and Cell Biology
Year: 2022

Olive Leaf Extract (OLE) as a Novel Antioxidant That Ameliorates the Inflammatory Response in Cystic Fibrosis

Authors: Allegretta, C., Difonzo, G., Caponio, F., Tamma, G., Laselva, O.
Journal: Cells
Year: 2023

In vivo treatment with calcilytic of CaSR knock-in mice ameliorates renal phenotype reversing downregulation of the vasopressin-AQP2 pathway

Authors: Ranieri, M., Angelini, I., D’Agostino, M., Matsumoto, T., Valenti, G.
Journal: Journal of Physiology
Year: 2024