Prof Dr. Yinyuan Ding | Tumorigenesis | Best Researcher Award

Prof Dr. Yinyuan Ding | Tumorigenesis | Best Researcher Award

Chongqing Medical University | China

Author Profile

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ORCID ID

Professor Yinyuan Ding

🌟 Professor of Oncology
🏥 Chongqing Medical University

🎓 Academic and Professional Background:

Professor Yinyuan Ding obtained a Ph.D. from Peking University in 2011 and pursued postdoctoral training at UT Southwestern Medical Center, where he was later promoted to Assistant Professor in 2018. In 2019, he returned to China and joined Chongqing Medical University as a professor. His research explores tumorigenesis and glucolipid metabolic disorders, focusing on the LRP1 receptor’s role in liver and vascular signaling, with implications for novel treatments for Hepatocellular Carcinoma (HCC) and Metabolic Associated Steatohepatitis-Liver Disease (MASLD).

🔬 Research and Innovations:

  • Principal Investigator
    2023-2026: “The role of LRP1 in hepatic glucose metabolism and HCC progression” (National Natural Science Foundation of China)
    2021: “The role of Asprosin in hepatocellular carcinoma” (Chongqing Municipal Human Resources Bureau)

 

  • Participant
    2015-2020: “VLDL and ApoE receptors metabolism” (NIH-NHLBI)
    2011-2015: “Cell signaling and cholesterol-lipoprotein receptors” (NIH)

📚 Journals Published:

Advanced Science, Elife, Science Signaling, EBioMedicine, JBC

🤝 Collaborations:

Collaborates with Joachim Herz (UT Southwestern Medical Center, USA)

👥 Professional Memberships:

Director of the China Branch, International Atherosclerosis Society

🧬 Areas of Research:

  • Oncology
  • Tumorigenesis
  • Hepatology
  • Lipoprotein & Lipid Research

📝 Contributions:

Professor Ding’s groundbreaking research on LRP1 has revealed its multifaceted roles in regulating cholesterol and glucose metabolism. His work identified a critical mechanism by which LRP1 affects hepatic insulin resistance, dyslipidemia, and HCC progression. This novel insight into LRP1’s function opens pathways for innovative therapeutic strategies for cancer and metabolic disorders.

Conclusion:

In summary, Professor Yinyuan Ding is a distinguished expert in oncology and hepatology, with a strong focus on the molecular mechanisms of tumorigenesis and lipid metabolism disorders. His innovative research on LRP1 has led to significant breakthroughs in understanding liver disease and cancer progression, paving the way for novel therapeutic strategies. With a wealth of experience from top institutions and numerous prestigious publications and patents, Professor Ding continues to make impactful contributions to the field of cancer research, driving advancements in both basic science and clinical applications. 🌟

📊🔬NOTABLE PUBLICATION:

1. LRP1 facilitates hepatic glycogenesis by improving the insulin signaling pathway in HFD-fed mice

  • Authors: Guo, X., Pu, J., Tang, Z., Liu, T., Ding, Y.
  • Journal: Animal Models and Experimental Medicine
  • Year: 2024

2. Erratum: Correction: LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis

  • Authors: Xian, X., Ding, Y., Dieckmann, M., Tsai, S., Herz, J.
  • Journal: eLife
  • Year: 2017 (Erratum published in 2024)

3. Loss of LRP1 Promotes Hepatocellular Carcinoma Progression via UFL1-Mediated Activation of NF-κB Signaling

  • Authors: Guo, X., Yang, F., Liu, T., Herz, J., Ding, Y.
  • Journal: Advanced Science
  • Year: 2024

Prof Shengping Hou | Immunotherapy | Best Researcher Award

Prof Shengping Hou | Immunotherapy | Best Researcher Award

Beijing Tongren Hospital, Capital Medical University | China

AUTHOR PROFILE

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Orcid ID

EARLY ACADEMIC PURSUITS

Shengping Hou, Ph.D., began his academic journey at Sun Yat-sen University in China, where he obtained his Ph.D. in Ocular Immunology in 2009. His doctoral research laid the foundation for his future contributions to ocular immunology, particularly focusing on the genetic aspects of ocular diseases. Following his Ph.D., Dr. Hou furthered his expertise with a postdoctoral fellowship at the University of California, San Francisco, specializing in Ocular Stem Cell Biology, which he completed in 2016.

PROFESSIONAL ENDEAVORS

Dr. Hou’s professional career commenced at The First Affiliated Hospital of Chongqing Medical University, where he served as an Associate Professor from 2009 to 2015. He was later promoted to Professor, a position he held until 2023. During his tenure, he was also a key figure at the Chongqing Key Laboratory of Ophthalmology. In 2023, Dr. Hou transitioned to Beijing Tongren Hospital, where he now serves as the Director of the Beijing Institute of Ophthalmology and continues his professorship at Capital Medical University.

CONTRIBUTIONS AND RESEARCH FOCUS ON IMMUNOTHERAPY

Dr. Hou’s research has primarily centered on the genetic and immunological underpinnings of ocular diseases, particularly uveitis and Behcet’s disease. His work has involved extensive genetic studies, including the investigation of VKH syndrome and the role of complement component 4 copy number variants in ocular pathogenesis. His notable projects have been consistently supported by grants from the National Natural Science Foundation and other key R&D initiatives in China.

IMPACT AND INFLUENCE

Dr. Hou’s contributions have earned him significant recognition in the scientific community. He has been honored with several prestigious awards, including the First Prize for Achievement in Science and Technology from both Chongqing and the Chinese Health Ministry. His research findings have been widely disseminated through invited lectures and presentations at major international conferences, enhancing the understanding of genetic influences in ocular diseases.

ACADEMIC CITATIONS

Throughout his career, Dr. Hou has been an active member of the Chinese Ocular Immunology Society and has served as an ad hoc reviewer for several high-impact journals such as Nature Reviews Rheumatology, Advanced Science, and eBioMedicine. His work has been extensively cited by peers, reflecting the significant impact of his research on the field of ocular immunology.

LEGACY AND FUTURE CONTRIBUTIONS

Dr. Hou’s legacy in the field of ophthalmology is marked by his dedication to uncovering the genetic mechanisms underlying ocular diseases. As the Director of the Beijing Institute of Ophthalmology, he continues to lead groundbreaking research and mentor the next generation of scientists. His future contributions are poised to further advance the understanding and treatment of ocular conditions, solidifying his status as a leading figure in ophthalmic research.

NOTABLE PUBLICATION: